ECM‐Like Adhesive Hydrogel for the Regeneration of Large Corneal Stromal Defects (Adv. Healthcare Mater. 21/2023)
نویسندگان
چکیده
Corneal Regeneration In article 2300192 by Lixin Xie, Qingjun Zhou, and co-workers, a photoreactive adhesive hydrogel that mimics the extracellular matrix (mainly composed of gelatin hyaluronic acid) is designed to treat large-diameter (≥6 mm) corneal defects, which effectively promotes epithelial, stromal, neural regeneration while preventing scar formation. It also holds great improvement expansion potential in future applications, such as ophthalmic surgery, cell drug delivery, tissue engineering, 3D bioprinting.
منابع مشابه
Nerve regeneration by human corneal stromal keratocytes and stromal fibroblasts
Laser refractive surgeries reshape corneal stroma to correct refractive errors, but unavoidably affect corneal nerves. Slow nerve regeneration and atypical neurite morphology cause desensitization and neuro-epitheliopathy. Following injury, surviving corneal stromal keratocytes (CSKs) are activated to stromal fibroblasts (SFs). How these two different cell types influence nerve regeneration is ...
متن کاملTopical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals.
Purpose The purpose of this study was to determine the safety of topical ocular administration of a cross-linked, modified hyaluronic acid (xCMHA-S) hydrogel, and its effectiveness in accelerating repair and closure of acute and nonhealing corneal ulcers in companion animals as a veterinary treatment and its utility as a model for therapy in human corneal ulceration. Methods Two concentration...
متن کاملMetamaterials: Snapping Mechanical Metamaterials under Tension (Adv. Mater. 39/2015).
By exploiting snap-through instabilities, D. Pasini and co-workers design a damage-tolerant mechanical metamaterial that snaps sequentially under tension, thereby accommodating a very large deformation up to 150%. On page 5931, they describe how the nonlinear mechanical response of the metamaterial can be robustly programmed by tuning the architecture of its unit cell.
متن کاملstudy of cohesive devices in the textbook of english for the students of apsychology by rastegarpour
this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
Nanoelectrodes: Large-Scale Nanoelectrode Arrays to Monitor the Dopaminergic Differentiation of Human Neural Stem Cells (Adv. Mater. 41/2015).
A large-scale homogeneous nanocup-electrode array (LHONA) capable of noninvasive real-time monitoring of dopamine generation from human neural-stem-cell-derived midbrain neurons is described by J.-W. Choi, K.-B. Lee, and co-workers on page 6356. LHONA, fabricated through sequential laser interference lithography (LIL), is a conductive cell-culture platform that is extremely important for electr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2023
ISSN: ['2192-2640', '2192-2659']
DOI: https://doi.org/10.1002/adhm.202370125